Unveiling the Endometrium's Microbial Landscape
For decades, the human uterus was considered a sterile environment. However, recent scientific advances and the application of Next-Generation Sequencing (NGS) have revealed that the endometrium hosts its own unique microbial community. This discovery has opened a new frontier in reproductive medicine.
A healthy endometrium is typically characterized by a Lactobacillus-dominant microbiome. An imbalance, or dysbiosis, particularly the presence of pathogenic bacteria, can lead to Chronic Endometritis (CE). CE is often asymptomatic but is a major underlying cause of infertility.
Prevalence in Recurrent Implantation Failure (RIF)
Prevalence in Recurrent Pregnancy Loss (RPL)
From Dysbiosis to Infertility
The health of the endometrial microbiome has profound implications for fertility treatment outcomes. Our Endobiome test identifies issues before they compromise a patient's journey.
Optimal Microbiome
Dominated by Lactobacillus spp. (>90%). Research indicates that a Lactobacillus abundance of over 90% is critical for a healthy endometrial environment, significantly correlating with successful embryo implantation and higher live birth rates.
Dysbiotic Bacteria
Presence of Bifidobacterium, Prevotella, Sneathia, Veillonella, Atopobium. A non-Lactobacillus-dominant profile linked to microbial dysbiosis and implantation issues.
Pathogenic Bacteria
Staphylococcus, Streptococcus, Enterococcus, E. coli, Klebsiella, Mycoplasma, Ureaplasma. Strongly correlated with chronic endometritis, implantation failure, and miscarriage.
Sample Requirements
Sample Type
Endometrial Fluid
The Endobiome Test
A sophisticated molecular diagnostic tool using NGS technology to analyze microbial DNA from endometrial tissue or fluid.
Comprehensive Detection
Identifies the full spectrum of bacteria, including beneficial and pathogenic species.
Lactobacillus Quantification
Measures percentage of Lactobacillus to determine if the microbiome is optimal.
Pathogen Identification
Specifically screens for key pathogens known to cause chronic endometritis.
Clinical Guidance
Clear assessment guiding targeted antibiotic therapy and probiotic supplementation.